Short form 1b human prolactin receptor down-regulates expression of the long form
نویسندگان
چکیده
منابع مشابه
Human prolactin receptor variants in breast cancer: low ratio of short forms to the long-form human prolactin receptor associated with mammary carcinoma.
Prolactin plays an essential role in the development of rodent mammary tumors and is a potent mitogen in human normal and cancerous breast tissues/cells. In this study, we have analyzed the expression of prolactin receptors, including the long receptor form (LF; stimulatory) and two novel short forms (SFs; S1a and S1b) derived from alternative splicing that are inhibitory of the activation indu...
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PRL (prolactin) has been implicated in the proliferation and differentiation of numerous tissues, including the prostate gland. However, the PRL-R (PRL receptor) signal transduction pathway, leading to the stimulation of cell proliferation, remains unclear and has yet to be mapped. The present study was undertaken to develop a clear understanding of the mechanisms involved in this pathway and, ...
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This study investigated the effectiveness of reactive incidental focus on form (FonF) for each learner with regard to different linguistic categories in meaning-oriented EFL classes. To this end, 30 hr of meaningful interactions of upper-intermediate EFL learners were audio-recorded in 2 free discussion classes. Instances of reactive incidental focus-on-form episodes (FFEs), where teachers offe...
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Magnocellular neurons of the supraoptic (SON) and paraventricular nuclei (PVN) show considerable plasticity during pregnancy and lactation. Prolactin receptors (PRL-R) have been identified in both these nuclei. The aim of this study was to investigate the cell type(s) expressing mRNA for the long form of prolactin receptor (PRL-R(L)) and to determine whether patterns of expression change during...
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The action of leptin via the long form of its receptor (LepRb) is central to the control of body energy homeostasis and neuroendocrine function, but the mechanisms by which LepRb regulates intracellular signaling have remained incompletely understood. Here we demonstrate that leptin stimulates the phosphorylation of STAT5 and ribosomal protein S6 in the hypothalamic arcuate nucleus in mice. In ...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2009
ISSN: 0952-5041,1479-6813
DOI: 10.1677/jme-09-0101